Kazuko Hasegawa Selected Research

Zonisamide (Zonegran)

1/2022	Long-Term Efficacy and Safety of Zonisamide for Treatment of Parkinsonism in Patients With Dementia With Lewy Bodies: An Open-Label Extension of a Phase three Randomized Controlled Trial.
1/2021	Efficacy and Safety of Zonisamide in Dementia with Lewy Bodies Patients with Parkinsonism: A Post Hoc Analysis of Two Randomized, Double-Blind, Placebo-Controlled Trials.
1/2020	Effect of zonisamide on parkinsonism in patients with dementia with Lewy bodies: A phase 3 randomized clinical trial.
1/2018	Adjunct zonisamide to levodopa for DLB parkinsonism: A randomized double-blind phase 2 study.
9/2015	Zonisamide improves wearing-off in Parkinson's disease: A randomized, double-blind study.
1/2007	Zonisamide improves motor function in Parkinson disease: a randomized, double-blind study.

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Kazuko Hasegawa Research Topics

Disease

36	Parkinson Disease (Parkinson's Disease) 09/2022 - 08/2003
7	Dementia (Dementias) 01/2022 - 08/2006
6	Parkinsonian Disorders (Parkinsonism) 01/2022 - 03/2002
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 09/2008
4	Dystonia (Limb Dystonia) 11/2006 - 08/2005
3	Sleepiness 07/2018 - 09/2004
3	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 06/2015 - 10/2009
2	Amyloidosis 01/2022 - 03/2011
2	Tauopathies 01/2022 - 01/2021
2	Synucleinopathies 01/2022 - 01/2020
2	Multiple System Atrophy 01/2021 - 01/2020
2	Mitochondrial Diseases (Mitochondrial Disease) 12/2019 - 04/2009
2	Psychotic Disorders (Schizoaffective Disorder) 12/2018 - 08/2006
2	Dyskinesias (Dyskinesia) 09/2015 - 07/2010
2	Muscle Weakness 06/2015 - 12/2013
2	Blepharospasm 03/2006 - 09/2005
2	Dystonic Disorders (Writer's Cramp) 03/2006 - 09/2005
2	Torticollis (Wryneck) 03/2006 - 09/2005
1	TDP-43 Proteinopathies 01/2022
1	Amyloid Plaque 01/2022
1	Corticobasal Degeneration 01/2021
1	Proteostasis Deficiencies 01/2021
1	Alzheimer Disease (Alzheimer's Disease) 01/2021
1	Pick Disease of the Brain (Pick's Disease) 01/2021
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2021
1	Inflammation (Inflammations) 10/2020
1	Hemorrhage 05/2019
1	Cognitive Dysfunction 12/2018
1	Fibrosis (Cirrhosis) 09/2016
1	Camptocormia 11/2015
1	Hallucinations (Hallucination) 09/2015
1	Gaucher Disease (Gaucher's Disease) 04/2015
1	GM2 Gangliosidoses (GM2 Gangliosidosis) 06/2014
1	Progressive Bulbar Palsy (Fazio Londe Syndrome) 12/2013
1	Acantholysis 01/2012
1	Skin Diseases (Skin Disease) 01/2012
1	Grover's disease 01/2012
1	Cutis Laxa 03/2011
1	X-Linked Bulbo-Spinal Atrophy 09/2010
1	Motor Neuron Disease (Primary Lateral Sclerosis) 09/2010
1	MELAS Syndrome (Syndrome, MELAS) 02/2010

Drug/Important Bio-Agent (IBA)

11	Levodopa (L Dopa)FDA LinkGeneric 01/2021 - 10/2003
6	Zonisamide (Zonegran)FDA LinkGeneric 01/2022 - 01/2007
6	SynucleinsIBA 01/2022 - 04/2012
6	Phosphotransferases (Kinase)IBA 01/2018 - 06/2005
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2012
5	ropinirole (Requip)FDA LinkGeneric 01/2021 - 10/2007
5	Leucine (L-Leucine)FDA Link 01/2018 - 04/2007
3	PrionsIBA 01/2022 - 01/2021
3	rotigotine FDA Link 12/2014 - 09/2013
2	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2021
2	Glucosylceramidase (Glucocerebrosidase)IBA 01/2018 - 04/2015
2	Carbidopa (Lodosyn)FDA LinkGeneric 01/2018 - 01/2016
2	Pramipexole (Mirapex)FDA LinkGeneric 07/2012 - 10/2003
2	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 08/2008 - 06/2007
2	Botulinum Toxins (Botulinum Toxin)IBA 03/2006 - 09/2005
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Dopamine Agonists (Dopamine Agonist)IBA 01/2021
1	VimentinIBA 11/2020
1	Glial Fibrillary Acidic ProteinIBA 11/2020
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2020
1	TabletsIBA 01/2020
1	Fibrinogen (Factor I)FDA Link 05/2019
1	Acetylcholine (Acetylcholine Chloride)FDA Link 12/2018
1	Donepezil (Aricept)FDA LinkGeneric 12/2018
1	ApolipoproteinsIBA 12/2018
1	HydrolasesIBA 01/2018
1	Leucine-Rich Repeat Serine-Threonine Protein Kinase-2IBA 01/2018
1	Delayed-Action PreparationsIBA 07/2017
1	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2017
1	Dopamine (Intropin)FDA LinkGeneric 01/2017
1	Serotonin (5 Hydroxytryptamine)IBA 01/2017
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 01/2017
1	fluorodopa F 18IBA 01/2017
1	Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 01/2017
1	Creatine Kinase (Creatine Phosphokinase)IBA 11/2015
1	Riluzole FDA LinkGeneric 06/2015
1	DNA (Deoxyribonucleic Acid)IBA 03/2015
1	NucleotidesIBA 03/2015
1	G(M2) Ganglioside (Ganglioside GM2)IBA 06/2014
1	LipofuscinIBA 06/2014
1	Biomarkers (Surrogate Marker)IBA 12/2013
1	Desmosomal CadherinsIBA 01/2012
1	Keratin-5 (Keratin 5)IBA 01/2012
1	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 01/2012
1	GelsolinIBA 03/2011
1	Androgen Receptors (Androgen Receptor)IBA 09/2010
1	polyglutamineIBA 09/2010
1	Leuprolide (Lupron)FDA LinkGeneric 09/2010
1	istradefyllineIBA 07/2010
1	Pharmaceutical PreparationsIBA 07/2010
1	Mitochondrial DNA (mtDNA)IBA 02/2010

Therapy/Procedure

7	Therapeutics 01/2021 - 08/2003
2	Activities of Daily Living (ADL) 12/2013 - 10/2007
1	Wearable Electronic Devices 09/2022
1	Emergency Treatment 05/2019
1	Perioperative Period 09/2016
1	Liver Transplantation 09/2016
1	Tracheostomy 06/2015
1	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 06/2015